Bone marrow failure or hypoproliferative anaemia (haematological malignancy, marrow suppression by chemotherapy or radiotherapy, Aplastic anaemia, MDS, myelofibrosis

Severe nutritional anaemia (Iron, folate, or vitamin B12 deficiency) especially in elderly patients with angina or CCF

Severe Haemolytic anaemia- when anaemia is poor tolerated and Hb < 7 g/dl