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Thigh - M1152/98

THIGH

Spices No: M1152/98

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GROSS DESCRIPTION
The exhibit displays large intramuscular well circumscribed liposarcoma displaying a variegated surface. The solid areas have tan to grey hemorrhagic surfaces. The cystic spaces are variable in size and appear empty.
HISTOPATHOLOGY DESCRIPTION
Liposarcoma shows marked variation in cell sizes accompanied by the presence of bizarre stromal cells with marked hyperchromasia. A varying number of lipoblast can be found,however the presence of lipoblast is not required for the diagnosis.
DIAGNOSIS
Liposarcoma
BAHASA MELAYU
Penerangan kasar: Spesimen liposarcoma menunjukkan permukaan yang mempunyai warna berlainan. Biasanya akan ada kawasan nekrosis atau tisu mati dah juga haemorrhagic.
Penerangan histopatologi: Liposarcoma terdiri daripada sel lemak yang menunjukkan perbezaan ketara dari segi saiz dan biasanya terdapat sel stroma yang sangat atipikal dan mempunyai nukleus yang gelap. Sel lemak lipoblast atau sel lemak tidak matang juga boleh dilihat dalam tisu liposarcoma.
Diagnosis: Liposarcoma

Leg : M1012/93C1

LEG

SPICES No. M1012/93C1

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GROSS DESCRIPTION
Undifferentiated pleomorphic sarcoma usually large, unencapsulated with grey firm heterogenous cut surface. It has no distinctive macroscopic features except that it has frequent necrosis and haemorrhage.
HISTOPATHOLOGY DESCRIPTION
The tumour cells arranged in storiform pattern, irregular fascicles, with variable cellularity. The cells are pleomorphic and bizarre with foamy cytoplasm and marked atypia, in background of inflamed collagenous stroma.
DIAGNOSIS
Undifferentiated pleomorphic sarcoma

Humerus : M1197/00

HUMERUS

Spices No: M1197/00

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GROSS DESCRIPTION
The exhibit displays large solid, soft and friable, greyish white intramedullary tumour located mainly at diaphyseal-metaphyseal portion of long bone. The tumour involved the cortex and extend into surrounding soft tissue. Areas of necrosis can be observed. Areas of hemorrhage commonly present.
HISTOPATHOLOGY DESCRIPTION
Classical ewing sarcoma shows uniform small round cells with stippled chromatin pattern and inconpicuous nucleoli in scanty cytoplasm. Hormer-Wright rosette can be observed.
DIAGNOSIS
Ewing sarcoma

Soft Tissue Mass

SOFT TISSUE MASS

Spices No: S003/2021

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GROSS DESCRIPTION
The exhibit displays well circumscribed tumour with a uniform glistening yellow to pale-tan cut surface. Superficial lipoma are typically <5cm, whereas deep seated may reach up to 20cm.
HISTOPATHOLOGY DESCRIPTION
X0.2
X10
Lipoma is composed of lobules of mature adipocytes separated by thin fibrous septae. These adipocytes exhibit large univacuolated cytoplasm with nuclei pushed to the periphery. No atypical stromal cell or immature adipocytes observed.
Fluorescence in situ hybridisation (FISH) shows non-amplified MDM2 gene.
DIAGNOSIS
Lipoma
BAHASA MELAYU
Pesakit lelaki berumur 40 tahun, ketumbuhan di bahagian lengan kanan
Jenis pembedahan: Pemotongan/eksisi tumor
Diagnosis: Lipoma (tumor daripada sel lemak, bukan kanser)
Status: Pesakit telah sihat sepenuhnya
Penerangan kasar: Spesimen menunjukkan ketumbuhan benigna iaitu ketumbuhan yang tidak agresif dan tidak merebak ke bahagian tubuh yang lain. Ketumbuhan ini mempunyai permukaan yang berwarna kekuningan seperti tisu lemak normal. Biasanya saiz lipoma adalah kurang dari 5cm. Sesetengah lipoma yang terletak di bahagian dalam tisu atau daging boleh memcapai sehingga 20cm.
Penerangan histopatologi: Di bawah mikroskop, lipoma terdiri daripada sel lemak yang matang dimana hanya terdapat univacuolated sitoplasma dengan nukleus kecil terletak di tepi sel.

Proximal Tibia

PROXIMAL TIBIA

Spices No: M1179/99A

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GROSS DESCRIPTION
The exhibit displays ill defined large destructive tumour over proximal part of the tibia involving the epiphysis and metaphysis. The tumour is infiltrative, destroying the overlying cortex and extending into the surrounding soft tissue. It exhibit heterogenous tan to brown mass.
HISTOPATHOLOGY DESCRIPTION
Osteosarcoma shows malignant osteoid deposited in a lace like pattern or as delicate trabeculae. The malignant cells are pleomorphic with irregular hyperchromatic nuclei and high mitotic activity.
DIAGNOSIS
Osteosarcoma
QUIZ
The type(s) of osteosarcoma include(s):
A. Osteoblastic [T/F]
B. Chondroblastic [T/F]
C. Fibroblastic [T/F]
D. Telangiectatic [T/F]
E. Lymphoblastic [T/F]
Answers: T T T T F

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Musculoskeletal System